Friday, 3 January 2025
Sooraj Pancholi all set to essay Veer Hamirji Gohil in his first biopic! A heroic war based Film to revolve around the Somnath Temple
Apoorva Arora’s Short Film Lipstick Wins Best Short Film Award at Jalgaon Film Festival
Ishq Jabariya Actress Siddhi Sharma Finds Peace and Flavor in Rajasthan : . It’s something I really miss here in Mumbai because
कोकिलाबेन धीरूभाई अंबानी हॉस्पिटलमध्ये अत्याधुनिक CAR-T थेरपीने रुग्णाला आक्रमक रिलॅप्स्ड लिम्फोमातून पूर्णपणे बरे केले
3९ वर्षाचे रिजेश यांच्यासाठी अत्याधुनिक CAR-T उपचारांमुळे २०२४ हे वर्ष नवीन आशेने समाप्त झाले आणि कॅन्सर मुक्त होऊन त्यांनी २०२५ चे स्वागत केले
नवी मुंबई, 03 जानेवारी, 2025: युनायटेड स्टेट्स ऑफ अमेरिकेमध्ये आपल्या करियरच्या शिखरावर असलेले कॉर्पोरेट प्रोफेशनल, ३९ वर्षांचे रिजेश आणि त्यांच्या कुटुंबियांना आक्रमक लिम्फोमाच्या रिलॅप्सने खूप मोठा धक्का दिला. हा लिम्फोमा पारंपरिक उपचारांना प्रतिरोधक असल्याने हे सगळेच अतिशय निराश झाले होते. पण कोकिलाबेन धीरूभाई अंबानी हॉस्पिटल, नवी मुंबईमध्ये अभिनव CAR-T थेरपीने रिजेशना कॅन्सरपासून पूर्णपणे मुक्ती मिळवून दिली आणि त्यांचा जीव वाचवला.
ऑक्टोबर २०२३ मध्ये समजले की रिजेशना डिफ्युज लार्ज बी-सेल लिम्फोमा (डीएलबीसीएल) झाला होता, हा नॉन-हॉजकिन लिम्फोमा (एनएचएल) च्या सर्वात सामान्य प्रकारांपैकी एक आहे. त्यांच्यावर स्टॅन्डर्ड फर्स्ट-लाईन उपचार केले गेले, यामध्ये आर-सीएचओपी (R-CHOP) केमोथेरपीचा देखील समावेश होता, यामध्ये सीएनएसमध्ये कॅन्सर पेशींना टार्गेट करण्यासाठी मेथोट्रेक्सेट थेट मणक्याच्या हाडाच्या फ्लुइडमध्ये दिले गेले. या उपचाराने सुरुवातीला काही आशाजनक परिणाम दाखवले पण दुर्दैवाने जून २०२४ मध्ये कॅन्सरने पुन्हा फणा वर काढला.
यावेळी या आजाराने अजून जास्त दुर्मिळ आणि आक्रमक स्वरूप धारण केले होते - हाय-ग्रेड डबल-हिट लिम्फोमा. यामधल्या आनुवंशिक असामान्यता असल्यामुळे हे स्टॅन्डर्ड उपचारांना प्रतिरोधक बनते. आजार जेव्हा दुसऱ्यांदा वर आला तेव्हा त्यामध्ये अजूनच गुंतागुंत निर्माण झालेली होती कारण लिम्फोमा मेंदू आणि मणक्याच्या हाडांपर्यंत पोहोचलेला होता. आता हा आजार उपचारांसाठी एक सर्वात कठीण कॅन्सर बनलेला होता. तेव्हा रिजेश कोकिलाबेन धीरूभाई अंबानी हॉस्पिटल, नवी मुंबईमध्ये हेमेटॉलॉजिस्ट आणि हेमेटो-ऑन्कोलॉजिस्ट, कन्सल्टन्ट बीएमटी आणि सेल्युलर थेरपी (सीएआर-टी) डॉ कुणाल गोयल यांच्याकडे उपचारांसाठी आले.
रिजेश यांच्यावर अतिशय काटेकोरपणे बहु-आयामी उपचार सुरु करण्यात आले. यामध्ये हाय-डोस मेथोट्रेक्सेटवर आधारित केमोथेरपी (MTR), CNS बूस्टसोबत संपूर्ण ब्रेनची रेडिओथेरपी (WBRT) आणि एक टार्गेटेड थेरपी एकलाब्रुटिनिब यांचा समावेश होता. MTR ला ब्लड ब्रेन बॅरियर भेदण्यासाठी आणि सेंट्रल नर्व्हस सिस्टिममध्ये लिम्फोमा पेशींना टार्गेट करण्यासाठी डिझाईन करण्यात आले होते. WBRT चा उपयोग संपूर्ण मेंदूमध्ये रेडिएशन पोहोचवण्यासाठी करण्यात आला होता, तर "बूस्ट" ने अशा विशिष्ट भागांवर अतिरिक्त रेडिएशन केंद्रित केले जिथे कॅन्सर होता. इतके सगळे प्रयत्न करून देखील लिम्फोमा तसाच राहिला आणि मग टीमने एक दुसरा दृष्टिकोन अवलंबिण्याचा निर्णय घेतला, या निर्णयाने आधुनिक वैद्यकशास्त्राच्या सीमा रुंदावल्या.
डॉ कुणाल गोयल यांनी (कैमेरिक अँटीजेन रिसेप्टर टी-सेल थेरपी) Chimeric Antigen Receptor T-cell किंवा CAR-T थेरपीचा उपयोग करण्याचा निर्णय घेतला. CAR-T एक प्रगत इम्युनोथेरपी आहे, यामध्ये कॅन्सर पेशी ओळखून नष्ट करण्यासाठी रुग्णाच्या रोगप्रतिकार पेशींमध्ये बदल केले जातात. डॉ कुणाल गोयल यांनी आपल्या निर्णयाविषयी सांगितले, "CAR-T थेरपी कॅन्सरच्या उपचारांमध्ये एक नवी क्रांती घेऊन आली आहे. ज्यांच्यासाठी उपचारांचे इतर पर्याय समाप्त झाले आहेत अशा आक्रमक आणि रिलॅप्स्ड लिम्फोमाच्या रुग्णांसाठी हे खूपच उपयुक्त आहे. CAR-T मध्ये रुग्णांच्या रोगप्रतिकार शक्तीचा उपयोग केला जातो. या प्रक्रियेमध्ये रुग्णाच्या टी-पेशींना सहभागी केले जाते, या सफेद रक्तपेशी असतात, ज्या शरीराला संसर्ग आणि आजारांविरोधात लढण्यासाठी मदत करतात, प्रयोगशाळेमध्ये या पेशींना कॅन्सर पेशींना टार्गेट करण्यासाठी तयार केले जाते आणि पुन्हा रुग्णाच्या रक्तप्रवाहामध्ये पुन्हा सोडले जाते."
रिजेशच्या टी-पेशी काढून एका विशेष प्रयोगशाळेत पाठवण्यात आल्या, याठिकाणी त्यांच्या पृष्ठभागावर कैमेरिक अँटीजेन रिसेप्टर (CAR) हा एक सिंथेटिक रिसेप्टर एक्स्प्रेस करण्यासाठी अनुवांशिक पद्धतीने इंजिनीयर करण्यात आले. या CAR ला लिम्फोमा पेशींच्या पृष्ठभागावर आढळणारे प्रोटीन ओळखण्यासाठी आणि त्याच्याशी जोडले जाण्यासाठी डिझाईन करण्यात आले होते. T-पेशींना CAR सोबत बदलले गेल्यानंतर त्यांना प्रयोगशाळेमध्ये मल्टिप्लाय केले गेले आणि पुन्हा त्यांच्या शरीरातील रक्तप्रवाहामध्ये सोडले गेले. या "री-इंजिनीयर्ड" CAR-T पेशी आता लिम्फोमा पेशींना अचूकपणे टार्गेट करून नष्ट करू शकत होत्या.
१९ नोव्हेंबर २०२४ रोजी रिजेशवर कोकिलाबेन धीरूभाई अंबानी हॉस्पिटल, नवी मुंबईमध्ये CAR-T थेरपी केली गेली आणि बदलण्यात आलेल्या CAR-T पेशींना त्यांच्या शरीरातील रक्तप्रवाहामध्ये सोडण्यात आले. रिजेशसाठी ही जीव वाचवण्याची शेवटची आणि कदाचित सर्वात चांगली संधी होती. CAR-T थेरपीमुळे घडून आलेला परिणाम हा निव्वळ एक चमत्कार होता. एका महिन्यानंतर पीईटी सीटी स्कॅनमध्ये (PET CT scan) समजले की कॅन्सर पूर्णपणे बरा झाला होता आणि रिजेशच्या शरीरामध्ये लिम्फोमा आढळून आला नाही!
कोकिलाबेन धीरूभाई अंबानी हॉस्पिटल, नवी मुंबईचे चीफ ऑपरेटिंग ऑफिसर डॉ शशिकांत पवार यांनी सांगितले, "कॅन्सर पूर्णपणे बरा होणे ही बाब वैद्यकीय तंत्रज्ञानातील प्रगतीबरोबरीनेच आधुनिक उपचारांची शक्ती देखील दर्शवते. कॅन्सरवरील उपचारांमध्ये CAR-T थेरपी सर्वात आघाडीवर आहे आणि आम्ही प्रयत्न करत आहोत की रिजेशसारख्या रुग्णांना आधुनिक वैद्यकीय प्रगतीचे सर्वात चांगले लाभ मिळावेत, जेणेकरून ते सर्वात गंभीर आणि गुंतागुंतीच्या आजारातून बाहेर यावेत. या केसने रुग्ण आणि कोकिलाबेन धीरूभाई अंबानी हॉस्पिटल नवी मुंबईची टीम या दोघांनाही वर्ष २०२४ ला अतिशय आनंदाने निरोप देण्याची संधी दिली. ही केस आठवण करून देते की, वैद्यकीय क्षेत्राचे भवितव्य हेच असणार आहे आणि ते उज्वल आहे."
Thursday, 2 January 2025
Deltin’s ‘MegaPlay’ Event Redefined Year-End Festivities with Six Days of Spectacular Performance
Official First Look Poster of "Mukhoshe Manushe Khela - Dark Mind Games": A Corporate Thriller**Kolkata, India - January 3,
Imperfecto Mehfil by Bel Cibo Debuts in Delhi’s Iconic Omaxe Chowk, Chandni Chowk
Imperfecto
Spanning over 6,000 sq. ft., the restaurant sets a new standard for Mughal-inspired dining
In the heart of Delhi’s historic Chandni Chowk, Omaxe Chowk is redefining the culinary landscape with the opening of Imperfecto Mehfil, the latest venture by Bel Cibo. This restaurant spanning over 6000 sq.ft. combines the grandeur of Mughal-inspired interiors with the flavors of authentic Mughlai cuisine, offering guests a royal dining experience steeped in heritage.
Imperfecto Mehfil immerses diners to a regal era with its baithak-style seating, vintage chandeliers, and intricately designed décor. The menu showcases culinary artistry with signature dishes like Tandoori Raan, Nargisi Kofta, and Akbari Dal, complemented by refreshing beverages such as Mohabbat ka Sharbat. Blending India’s rich heritage with contemporary dining, the restaurant reimagines the culinary experience to deliver a bold fusion of tradition and innovation.
Jatin Goel, Executive Director of Omaxe Group, said: "Our vision for Omaxe Chowk is to establish it as a premier culinary destination, offering a diverse range of dining experiences that celebrate both local and global flavors. Dawatpur, India’s largest food court, is a key part of this vision, featuring an exceptional mix of traditional street food and international cuisine, while also expanding our portfolio with more premium dine-in options. With the addition of Imperfecto Mehfil, we are further enhancing this vision, introducing a refined dining experience that blends regal Mughal aesthetics with exceptional culinary craftsmanship. Omaxe Chowk is quickly becoming the go-to destination for food lovers, making it a true cultural and culinary landmark."
Omaxe Chowk, located in the heart of Chandni Chowk, Delhi, is a premier retail and dining destination that seamlessly blends heritage with modernity. It attracts visitors from all over, offering a diverse shopping experience with a wide range of fashion, accessories, home décor, and electronics, catering to every shopper's needs. Beyond shopping, Omaxe Chowk is a food lover's paradise, featuring a variety of culinary delights from local street food to international flavors. With entertainment options for family outings, social gatherings, or a relaxing day with friends, Omaxe Chowk’s prime location, world-class amenities, and diverse offerings make it the ultimate destination to shop, dine, and unwind—all under one roof.
Sterling Brookstone Coorg A Gateway to Serenity and Exploration
Conveniently located near Madikeri, a hub of scenic landscapes and rich heritage, the resort provides easy access to iconic attractions such as breathtaking waterfalls, lush coffee plantations, and panoramic viewpoints. With a pleasant climate throughout the year, sprawling greenery, and stunning vistas of the pristine Ghats, Sterling Brookstone Coorg sets the stage for an invigorating getaway. Whether exploring mesmerizing trails or savouring soulful creations by the Chef, every moment at this resort promises to be enriching.
The resort features villa and cottage-style accommodations that offer stunning views, seamlessly blending modern amenities with the serenity of nature. Guests can enjoy an array of facilities, including a swimming pool, banquet hall, and an upcoming spa, making it an ideal destination for a well-rounded holiday. Dining at the in-house restaurant, Planter’s Kitchen, is a culinary journey, with authentic Kodagu cuisine complemented by a variety of regional and international dishes.
“Sterling Brookstone Coorg is designed to offer a truly immersive experience in one of India’s most picturesque destinations. It is a sought-after getaway for holidaymakers, blending heritage, culture, natural splendor, adventure, wildlife, and a perfect year-round climate. Our aim is to provide guests with not just a stay but an opportunity to connect with this vibrant ecosystem that rejuvenates the body and soul, heightening all five senses,” said Vikram Lalvani, MD & CEO, Sterling Holiday Resorts.
Beyond the resort, Sterling Brookstone Coorg serves as a base for exploring Coorg’s rich heritage and natural wonders. Guests can visit Abbey Falls to witness the majestic cascades nestled amidst coffee plantations or explore Madikeri Fort, which offers a glimpse into history and stunning panoramic views. At Raja’s Seat, travelers can relax in tranquil gardens and enjoy breathtaking sunsets over the valleys. Wildlife enthusiasts can visit Dubare Elephant Camp for memorable interactions with elephants, while those seeking spiritual serenity can find it at the Namdroling Buddhist Monastery, also known as the Golden Temple, with its vibrant Tibetan architecture and peaceful ambiance.
About Sterling Holiday Resorts Ltd.
Sterling Holiday Resorts Limited is a leading hospitality company in India that owns & manages more than 3000 keys, across 57 resorts, hotels and retreats, at 48 unique destinations. The company caters to leisure stays, Meetings and Conferences (MICE), Destination Weddings, Reunions, Picnics and Group travel. Under its brands – Sterling & Nature Trails, the company offers a network of hotels across hills, beaches, jungles, waterfront, adventure, heritage, pilgrimage and drive-to locations.
Sterling has resorts at some of the best holiday destinations in India, located in Alleppey, Anaikatti, Athirappilly, Badami, Bokaro, Corbett, Chail, Coorg, Darjeeling, Dehradun, Gangtok, Gir, Goa, Godavari, Guruvayur, Haridwar, Kalimpong, Kanha, Karwar, Kodaikanal, Kufri, Lonavala, Madurai, Manali, Mount Abu, Munnar, Mussoorie, Nainital, Ooty, Panchgani, Pench, Puri, Pushkar, Ranthambore, Rishikesh, Sariska, Shimla, Srinagar, Thekkady, Tiruvannamalai, Udaipur, Vythiri, Wayanad, Yelagiri and Yercaud.
Nature Trails operates eco-adventure retreats at 3 unique destinations in Maharashtra: Durshet, Kundalika and Sajan. Sterling Holiday Resorts Limited is a part of Fairfax Financial Holdings Limited and is a 100% independently managed, wholly owned subsidiary of Thomas Cook (India) Limited (TCIL), India's leading integrated travel and travel-related financial services.
For more information and bookings, log on to www.sterlingholidays.com
Bon Mama Opens at Reach 3Roads, Redefining Gurugram's Culinary Scene
Bon Mama's menu promises to be a gastronomic delight, offering an array of options tailored to diverse palates. Guests can savor soups, salads, chaats, and kebabs, or indulge in signature sizzlers like Stuffed Cottage Cheese Steak and Roast Leg of Chicken. For comfort food enthusiasts, there's an extensive selection of burgers, pastas, and pizzas, along with timeless North Indian classics. To conclude the meal, dessert lovers can enjoy Nutmeggy Pancakes, rich mousse, or brownies with ice cream. A curated list of mocktails, smoothies, and hot and cold beverages ensures there's something for everyone.
The arrival of Bon Mama reinforces Reach 3Roads' position as a premier culinary destination, expanding its portfolio of diverse dining experiences and appealing to both food aficionados and families looking for memorable outings.
Nandini Taneja, Regional Director - Leasing, Reach Group, shared her thoughts: "We're delighted to welcome Bon Mama to Reach 3Roads. Our goal is to consistently offer visitors a diverse and memorable experience, and Bon Mama perfectly embodies this vision. Its unique menu and inviting atmosphere will undoubtedly resonate with food lovers and families looking for something special."
Harneek Singh, Director, Bon Mama, added: "The launch of Bon Mama at Reach 3Roads is an exciting chapter for us. Our philosophy has always been about crafting dining experiences where exceptional cuisine meets heartfelt hospitality."
Furthermore, Harmeek Singh, Director, Bon Mama, said: "We're excited to bring this vision to life here, offering a space where casual meals and cherished moments blend seamlessly."
Reach Group has been a trusted force in real estate for more than a decade. We hold a portfolio comprising various successful projects. Trusted by some of the world's most recognizable brands, we are committed to delivering exceptional spaces that inspire, empower, and contribute to a better future
Bon Mama Opens at Reach 3Roads, Redefining Gurugram's Culinary Scene
Reach 3Roads, one of Gurugram's most sought-after retail and lifestyle hubs, has added another feather to its cap with the launch of Bon Mama, a premium dining experience located on the center's second floor. This exciting addition enriches the area's culinary scene with a fusion of Indian and continental flavors, an inviting ambiance, and top-notch service.
Bon Mama's menu promises to be a gastronomic delight, offering an array of options tailored to diverse palates. Guests can savor soups, salads, chaats, and kebabs, or indulge in signature sizzlers like Stuffed Cottage Cheese Steak and Roast Leg of Chicken. For comfort food enthusiasts, there's an extensive selection of burgers, pastas, and pizzas, along with timeless North Indian classics. To conclude the meal, dessert lovers can enjoy Nutmeggy Pancakes, rich mousse, or brownies with ice cream. A curated list of mocktails, smoothies, and hot and cold beverages ensures there's something for everyone.
The arrival of Bon Mama reinforces Reach 3Roads' position as a premier culinary destination, expanding its portfolio of diverse dining experiences and appealing to both food aficionados and families looking for memorable outings.
Nandini Taneja, Regional Director - Leasing, Reach Group, shared her thoughts: "We're delighted to welcome Bon Mama to Reach 3Roads. Our goal is to consistently offer visitors a diverse and memorable experience, and Bon Mama perfectly embodies this vision. Its unique menu and inviting atmosphere will undoubtedly resonate with food lovers and families looking for something special."
Harneek Singh, Director, Bon Mama, added: "The launch of Bon Mama at Reach 3Roads is an exciting chapter for us. Our philosophy has always been about crafting dining experiences where exceptional cuisine meets heartfelt hospitality."
Furthermore, Harneek Singh, Director, Bon Mama, said: "We're excited to bring this vision to life here, offering a space where casual meals and cherished moments blend seamlessly."
Reach Group has been a trusted force in real estate for more than a decade. We hold a portfolio comprising various successful projects. Trusted by some of the world's most recognizable brands, we are committed to delivering exceptional spaces that inspire, empower, and contribute to a better future.
AlphaVector’s Ninety-One Cycles Crosses 3 Million Bicycle Sales
Actor Sagar Wahi Joins the Cast of Chhathi Maiyya Ki Bitiya as Mayur: "In real life, I am very different from him"
Crack Academy’s 'Sarkari Naukri Mela' Comes to Patran: A Must-Attend Event for Government Job Aspirants
The Sarkari Naukri Mela promises to be a one-of-a-kind event that bridges the gap between students’ ambitions and the reality of cracking competitive exams. Attendees will gain access to exclusive insights from top educators and mentors on cracking exams like UPSC, SSC, Banking, Railways, and more. The event will include dynamic workshops where participants will learn exam-specific strategies, answer-writing techniques, and methods to approach high-pressure scenarios effectively.
Neeraj Kansal, Founder and CEO of Crack Academy, shares his vision for the event: “Government job exams are a gateway to a secure and impactful career, but preparation can often feel overwhelming. Through the Sarkari Naukri Mela, we aim to simplify the journey by equipping aspirants with clear guidance, innovative strategies, and confidence to succeed. This event is not just about preparation—it’s about inspiring students to dream big and providing them with the tools to achieve those dreams.”
With limited spots available, registrations are being accepted on a first-come, first-served basis. Crack Academy’s Sarkari Naukri Mela in Patran is the perfect opportunity for government job aspirations to take their dreams to the next level.
50 years of Emergency: Kangana Ranaut’s ‘Emergency’ set to bring history to the big screen
Wednesday, 1 January 2025
Envision 2025: India’s First Energy Festival Returns with the Theme‘Ground Zero for Net-Zero’ | January 30 - February 1, 2025
Chennai, January 2nd, 2025 — The climate crisis is no longer a distant warning—it is impacting our daily lives, demanding immediate attention and action. With an array of indigenous innovations and diverging technologies emerging worldwide, achieving a sustainable, net-zero future requires collective effort; no country, company, or community can do it alone.
To drive this momentum, IIT Madras Research Park (IITMRP), India’s leading deep-tech innovation and startup incubation ecosystem in association with India Energy Storage Alliance (IESA), is set to host Envision 2025 for its third edition from January 30 to February 1, 2025. With the theme for this edition, ‘Ground Zero for Net-Zero’, the event will bring together grassroots initiatives and global stakeholders in a united call to action.
Building on the success of Envision 2024, which attracted over 500 attendees and featured more than 50 expert speakers across 12+ technology focus areas—including the launch of the Zero to Green Alliance—this year’s conference aims to amplify its impact. Envision 2025 will highlight India’s collaborative potential in addressing climate challenges and advancing climate tech solutions, with a focus on the following technological areas:
- Green Buildings
- Solar and Wind Energy
- Electric Mobility
- Energy Storage
- Nuclear Energy
- Climate Finance
- Heating & Cooling
- Climate Policy
- Circular Economy
- Green Hydrogen
“With rapid advances in AI, electric vehicles, and related technologies, India’s per-capita power energy consumption is expected to increase rapidly. To transition to a developed economy and fulfil this energy requirement, we must be self-sufficient and enhance clean energy generation by creating a roadmap for moving toward a $300 billion industry. This will require a robust strategic, expert-oriented, and industrial approach with risk funding, collaboration, and replication of IITM Research Park models to facilitate an ecosystem to push the movement from labs to markets,” said Kris Gopalakrishnan, Co-Founder of Infosys, while speaking at the last EnVision conference in 2023.
The three-day event will feature expert sessions, panel discussions, deep-dive workshops and technology showcases, empowering stakeholders to turn climate commitments into actionable strategies. This year’s conference will also host the second edition of “Pitch to Win” inviting innovative climate tech solutions from startups.
Envision 2025 presents a pivotal opportunity to shape a sustainable, economically viable, and socially inclusive energy future for the nation. IIT Madras Research Park encourages everyone’s participation in this crucial dialogue to advance climate action.
To know more and register, visit https://10x.respark.iitm.ac.